On a routine transcontinental flight, Flight 472 from Los Angeles to Sydney starts as any other journey—smooth and uneventful. The passengers are a mix of families, business travelers, and students, each settling in for the long flight over the Pacific Ocean. But hidden in the cargo hold is a dangerous shipment—a collection of rare and highly venomous spiders smuggled illegally for black-market trade.
Unbeknownst to the crew and passengers, the container housing the spiders is damaged during turbulence. The spiders escape, crawling through the ventilation systems and making their way into the cabin. At first, the passengers notice small disturbances—strange bites, skittering noises, and the occasional shadow darting past. Panic sets in when the first attack occurs: a passenger collapses from a venomous bite, and chaos ensues.
The plane’s captain, Captain Marissa Hayes, must keep her composure as the situation spirals out of control. The flight crew, led by head attendant Jake Porter, works frantically to calm the passengers and find a solution. Among the passengers is Dr. Emily Carter, an arachnologist who reluctantly steps forward to help identify the species and their weaknesses. She warns that some of the escaped spiders are not only venomous but capable of weaving webs that could clog essential airplane systems.
As the spiders spread, tensions rise. Some passengers band together to fight the infestation, while others panic, making the situation worse. The team must battle not only the deadly arachnids but also dwindling oxygen levels, cabin pressure issues, and the looming threat of engine failure caused by spider webs infiltrating the mechanics.
In a heart-pounding climax, the survivors attempt a daring plan: rerouting the plane for an emergency water landing while using makeshift flamethrowers and traps to contain the spiders. With teamwork, bravery, and sacrifice, they manage to land the plane safely, though not without losses.
The film ends with a chilling final scene: as the authorities secure the plane, one spider slips unnoticed into the rescue helicopter, hinting at a potential sequel.